The Origins Of Celiac Disease
The earliest recordings of the illness were documented by a Dutch physician Vincent Ketelaer in 1669; however, at that time it was not known that gluten was the problem.
What he did notice was a failure to thrive in some children and the prominence of mouth ulcers which is where the word sprue originates from.
It was not until Holland's supply of cereal grains became scarce after World War II (when they had to replace bread with vegetables), that some Dutch children, who it had been noted failed to thrive, started to improve in condition, gaining weight and strength.
The link between celiac disease and diet was finally made when the supplies of cereal grain returned to normal and those same children started to show signs of deteriorating again.
In the experiments that followed, gluten was eventually identified as the reason.
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